Functional assessment of mitochondrial DNA 4977 bp deletion in peptic ulcer disease
Background and Aim: A peptic ulcer is a breach in the gastric or duodenal mucosa down to the submucosa.There is evidence concerning the role of Reactive Oxygen Species (ROS) in the genesis of such ulcers production of intracellular ROS along mitochondria oxidative phosphorylation (OXPHOS) predisposes the deletion of 4977 bp mtDNA.The aim of the pre